Model mice handled with extracts and powders exhibit restored cognitive and motor capabilities.
Efforts to develop a breakthrough dementia drug are gaining attention, but conventional medicinal merchandise might present invaluable insights for preventive care.
A analysis group led by Specially Appointed Professor Takami Tomiyama of Osaka Metropolitan University’s Graduate School of Medicine has discovered that administering the dried seeds of a sort of jujube referred to as Ziziphus jujuba Miller var. spinosa, used as a medicinal herb in conventional Chinese medication, holds promise in restoring cognitive and motor operate in mannequin mice.
Promising Results from Model Mice Studies
By administering scorching water extracts of Zizyphi spinosi semen to mannequin mice with Alzheimer’s illness, frontotemporal dementia, Parkinson’s illness, and dementia with Lewy our bodies, the staff discovered that cognitive and motor capabilities have been restored.
Furthermore, when the seeds have been merely crushed into powder and administered to the mannequin mice, the staff found that the cognitive operate of the mannequin mice recovered to a degree above that of management mice. In addition, the powders apparently suppressed mobile getting old in older mice and improved their cognitive operate to the same degree as youthful mice.
Previously, members of the analysis staff reported individually that the pathology of dementia in mannequin mice improved with cognitive and motor capabilities restored after utilizing the Hawaiian herb mamaki and the Chinese herb Acorus gramineus.
“The results of our research will hopefully make it possible to develop dementia prevention products that middle-aged and elderly people can take at their own discretion,” Professor Tomiyama advised.
Reference: “Simply crushed Zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice” by Tomohiro Umeda, Ayumi Sakai, Rumi Uekado, Keiko Shigemori, Ryota Nakajima, Kei Yamana and Takami Tomiyama, 13 September 2024, eLife.
DOI: 10.7554/eLife.100737.1
Takami Tomiyama is a founding father of Cerebro Pharma Inc., and Tomohiro Umeda and Ayumi Sakai are/have been members of that firm. NOMON Co., Ltd. is a subsidiary of Teijin Ltd. and has the identical deal with as Teijin. Kei Yamana and Ryota Nakajima belong to each NOMON and Teijin. Cerebro Pharma and Teijin funded this research, mentioned the analysis plans and outcomes, and collectively utilized for a patent on ZSS. The different authors declare no competing pursuits.
