Health

Intestinal Bacteria – The Secret to Living to 100?

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Researchers from the University of Copenhagen have studied the intestine microbiome of healthy Japanese centenarians, discovering a novel mixture of intestinal micro organism and bacterial viruses which will contribute to their longevity.

We are pursuing the dream of immortality. We quick to keep healthy. Each 12 months, we make investments billions of {dollars} in healthcare to prolong our lifespan. Yet, some people effortlessly attain the century mark. What’s their secret?

Researchers from the Novo Nordisk Foundation Center for Protein Research on the University of Copenhagen have launched into a journey to find the solution.

Studying 176 healthy Japanese centenarians, the researchers discovered that the mixture of intestinal micro organism and bacterial viruses of those individuals is sort of distinctive.

“We are always eager to find out why some people live extremely long lives. Previous research has shown that the intestinal bacteria of old Japanese citizens produce brand-new molecules that make them resistant to pathogenic – that is, disease-promoting – microorganisms. And if their intestines are better protected against infection, well, then that is probably one of the things that cause them to live longer than others,” says Postdoc Joachim Johansen, who’s the primary creator of the brand new research.

Among different issues, the brand new research exhibits that particular viruses within the intestines can have a helpful impact on the intestinal flora and thus on our health.

“Our intestines contain billions of viruses living off and inside bacteria, and they could not care less about human cells; instead, they infect the bacterial cells. And seeing as there are hundreds of different types of bacteria in our intestines, there are also lots of bacterial viruses,” says Associate Professor Simon Rasmussen, the final creator of the brand new research.

Joachim Johansen provides that apart from the essential, new, protecting bacterial viruses, the researchers additionally discovered that the intestinal flora of the Japanese centenarians is extraordinarily attention-grabbing.

“We found great biological diversity in both bacteria and bacterial viruses in the centenarians. High microbial diversity is usually associated with a healthy gut microbiome. And we expect people with a healthy gut microbiome to be better protected against aging-related diseases,” says Joachim Johansen.

Once we all know what the intestinal flora of centenarians seems to be like, we will get nearer to understanding how we will improve the life expectancy of different individuals. Using an algorithm designed by the researchers, they managed to map the intestinal micro organism and bacterial viruses of the centenarians.

“We want to understand the dynamics of the intestinal flora. How do the different kinds of bacteria and viruses interact? How can we engineer a microbiome that can help us live healthy, long lives? Are some bacteria better than others? Using the algorithm, we are able to describe the balance between viruses and bacteria,” says Simon Rasmussen.

And if the researchers are ready to perceive the connection between viruses and micro organism within the Japanese centenarians, they might give you the chance to inform what the optimum stability of viruses and micro organism seems to be like.

Optimizing intestinal micro organism

More particularly, the brand new information on intestinal micro organism could assist us perceive how we must always optimize the micro organism discovered within the human body to shield it towards illness.

“We have discovered that if a virus pays a bacterium a go to, it might really strengthen the bacterium. The viruses we discovered within the healthy Japanese centenarians contained additional genes that might increase the micro organism. We discovered that they have been ready to increase the transformation of particular molecules within the intestines, which could serve to stabilize the intestinal flora and counteract irritation,” says Joachim Johansen, and Simon Rasmussen provides:

“If you discover bacteria and viruses that have a positive effect on the human intestinal flora, the obvious next step is to find out whether only some or all of us have them. If we are able to get these bacteria and their viruses to move in with the people who do not have them, more people could benefit from them.”

Even although this requires extra analysis, the brand new perception is critical, as a result of we’re ready to modify the intestinal flora.

“Intestinal bacteria are a natural part of the human body and of our natural environment. And the crazy thing is that we can actually change the composition of intestinal bacteria. We cannot change the genes – at least not for a long time to come. If we know why viruses and intestinal bacteria are a good match, it will be a lot easier for us to change something that actually affects our health,” says Simon Rasmussen.

Reference: “Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan” by Joachim Johansen, Koji Atarashi, Yasumichi Arai, Nobuyoshi Hirose, Søren J. Sørensen, Tommi Vatanen, Mikael Knip, Kenya Honda, Ramnik J. Xavier, Simon Rasmussen and Damian R. Plichta, 15 May 2023, Nature Microbiology.
DOI: 10.1038/s41564-023-01370-6



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