Science Saturday: Could antidepressants cause treatment-emergent mania?

In a examine revealed in Molecular PsychiatryMark Frye, M.D., a Mayo Clinic researcher and collaborators, investigated the chance of treatment-emergent mania in bipolar dysfunction when handled with antidepressants.

“We found that antidepressants that increase mitochondrial energetics (cells that extract energy from nutrients for sustaining life) may elevate the risk of treatment-emergent mania,” says Dr. Frye.

The elevated power expenditure of mania related to impulsivity, poor judgment, psychosis and loss of perception can drive high-risk behaviors, usually leading to hospitalization or incarceration. The aftermath of mania can have an everlasting unfavorable impact on the affected person’s high quality of life, explains Dr. Frye, the examine’s senior writer.

Dr. Frye specializes within the neurobiology of bipolar disorders. Bipolar dysfunction, previously referred to as manic depression, is a psychological health situation that causes excessive temper swings that embody emotional highs (mania or hypomania) and lows (depression).

“These data suggest categorizing antidepressants based on mitochondrial energetics may be of value,” says Dr. Frye.

Read the remainder of the article on the Center for Individualized Medicine weblog.


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