Below is an approximation of this video’s audio content material. To see any graphs, charts, graphics, photos, and quotes to which Dr. Greger could also be referring, watch the above video.
“Metastasis is the leading cause of cancer-[related death].” Cancer kills, as a result of most cancers spreads. For instance, the five-year survival price for women with localized breast most cancers is sort of 99 %, however that drops to simply 27 % in these with metastasized most cancers. Yet “our ability to eﬀectively treat metastatic disease has not changed signiﬁcantly in the past few decades.” You know issues are getting determined when there are papers like this: “Targeting Metastasis with Snake Toxins.”
Now, we do have built-in defenses––pure killer cells that roam the body killing off budding tumors, and I’ve movies on boosting pure killer cell exercise. But as I defined within the final video, there’s a fats receptor referred to as CD36 that seems to be essential for most cancers cells to unfold, and these most cancers cells reply to dietary fats consumption. But not all fats.
CD36 is upregulated by palmitic acid, as a lot as a 50-fold enhance inside 12 hours. Palmitic acid is a saturated fats present in junk food produced from palm oil, however it’s most concentrated in meat and dairy. This might clarify why, if you happen to take a look at “dietary fat and breast cancer mortality,” there was no distinction in threat of breast-cancer-speciﬁc loss of life for women within the highest versus lowest class of whole fats consumption. But, you’re about 50 % extra seemingly to die of breast most cancers if you happen to eat numerous saturated fats. The systematic evaluation and “…meta-analyses [conclude]… that saturated fat intake negatively impacts upon breast cancer survival.”
This might clarify why “intake of high-fat dairy, but not low-fat dairy, was related to a higher risk of mortality after breast cancer diagnosis.” If it was the dairy protein, like casein, that was an issue; the skim milk could be even worse. But no, it was the saturated butterfat, possibly as a result of it triggered that CD36-induced cancer-spreading mechanism. “…Women who consumed one or more servings per day of high-fat dairy had … [about a 50] percent higher risk of dying from breast cancer.”
We see the identical factor with “dairy intake in relation to prostate cancer survival.” “…Drinking high-fat milk [appeared to increase] the risk of dying from prostate cancer by as much as 600 percent in patients with localized prostate cancer,” however “low-fat milk was not associated with such an increase in risk.” So, it appeared to be the animal fats, reasonably than the animal protein, and that is constant with what Harvard researchers discovered within the United States.
More proof that the fats receptor CD36 is concerned is “…that the risk of colorectal cancer for meat consumption increased from [just doubling risk to octupling risk]”—multiplying the percentages of getting most cancers eight-fold for many who carry a particular sort of CD36 gene. So, “Is It Time to Give Breast Cancer Patients a Prescription for a Low-Fat Diet?” A most cancers analysis is a “teachable moment” if there ever was one to inspire individuals to make modifications to their life-style. But provision of evidence-based tips is essential, and also you don’t know, till you set it to the take a look at.
“A randomized, prospective, multicenter clinical trial to test the effect of a dietary intervention designed to reduce fat intake in women with resected, early-stage breast cancer…” (which means the women had their breast most cancers surgically eliminated and had been praying it doesn’t come again). The dietary intervention group dropped their fats consumption from about 30 % of energy down to 20 % of energy, dropping saturated fats consumption about 40 %, and maintained that 40-percent decrease consumption after one yr, three years, 5 years. And… “after approximately five years of follow-up, [the] women in the dietary intervention group had a 24-percent lower risk of relapse…”, a 24-percent decrease threat of the most cancers coming again.
That was the WINS research, the Women’s Intervention Nutrition Study. Then there was the Women’s Health Initiative research, the place once more, women had been randomized to drop their fats consumption down to about 20 % of energy, and once more, these within the dietary intervention group skilled elevated breast most cancers survival, which means “a dietary change may be able to influence breast cancer outcome[s].” And not solely was breast most cancers survival considerably higher; the women additionally skilled a discount in coronary heart illness and a discount in diabetes as just a little aspect bonus.
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