Below is an approximation of this video’s audio content material. To see any graphs, charts, graphics, photographs, and quotes to which Dr. Greger could also be referring, watch the above video.
Intro: This is the primary in a three-part sequence on most cancers metastasis. In this sequence, I’ll take a look at what dietary elements contribute to the unfold of most cancers, and what dietary interventions—and even particular meals—can reduce the danger of unfold, subsequently growing the possibilities of survival. Let’s go discover out.
Metastasis formation is the main reason for dying in most cancers sufferers. That’s how most individuals die of most cancers. It’s not the first tumor, however the most cancers spreading by the body. “[It’s] estimated that metastasis is responsible for [90 percent] of cancer deaths”, with little progress made in stopping the unfold regardless of our fashionable medical armamentarium. In truth, we will typically make it worse: Therapy-Induced Metastasis. All the everyday most cancers remedies, radiation, chemotherapy, surgical procedure—even simply poking the tumors with high quality needle biopsies—have the potential to contribute to the issue. I imply, you may think about how slicing round a tumor, severing the blood vessels, may lead to the migration of residual tumor cells. But why chemotherapy? How may chemo exacerbate metastases? Despite lowering the dimensions of main tumors, chemotherapy can change the encompassing tissues, leading to an elevated escape of most cancers cells into the blood stream. Sometimes chemo/surgical procedure/radiation are totally justified, however typically these remedies could make issues worse. If solely we had a manner to deal with the trigger of the most cancers spreading.
The improvement of antimetastatic therapies has been hampered by the truth that we haven’t been in a position to identification the cells that provoke metastasis. But then, this landmark examine was printed. Researchers discovered a subpopulation of human most cancers cells “unique in their ability to initiate metastasis”, all expressing high ranges of a fats receptor generally known as CD36, dubbed “the fat controller.” It seems palmitic acid or a high-fat weight loss program particularly boosts the metastatic potential of those most cancers cells. Where do you discover palmitic acid? Although initially found in palm oil, it’s most concentrated in meat and dairy. “Emerging evidence shows that palmitic acid . . . serves as a signaling molecule regulating the progression and development of many diseases at the molecular level”––and that’s the saturated fats that’s acknowledged by the CD36 receptor on the most cancers cells. And we all know that’s to blame, as a result of should you block the CD36 receptor, you block the metastases.
Now this was for a human most cancers; nonetheless, it was a human most cancers implanted into mice, however clinically (which means in most cancers sufferers), the presence of those CD36-studded metastasis-initiating cells does certainly correlate with a poor prognosis. For instance, CD36 seems to drive the development of mind tumors. If you take a look at the survival curves, these with tumors with much less CD36 expression lived considerably longer. The identical with breast most cancers mortality. No shock, since “CD36 [appears to play] a critical role in [the] proliferation, migration, and…growth of…breast cancer cells.” Inhibit CD36, and you’ll inhibit “the migration and invasion of the breast cancer cells.” Cancer cell migration and invasion earlier than and after CD36 inhibition.
And not simply in “human melanoma- and breast cancer-derived tumors.” Now we suspect that “…CD36…drives ovarian cancer progression and metastasis” too, since we will inhibit ovarian most cancers cell invasion and migration and block each lymph node and blood-borne metastasis by blocking CD36. We see the identical form of impact with prostate most cancers. Suppress the uptake of fats by prostate most cancers cells, and you’ll suppress the tumor. This was all studied with receptor-blocking medication and antibodies in a laboratory setting, although. If these metastasis-initiating most cancers cells notably depend on dietary fats to promote the unfold of most cancers, why not simply block the dietary fats within the first place?
Cancer cells love fats and ldl cholesterol. The cause why fats metabolism might gasoline most cancers’s unfold is as a result of there’s a lot vitality saved in fats. “Hence, … metastatic cells might take advantage of this feature to obtain the high amount of energy that is likely to be required for them to anchor and [set up shop throughout the body].”
“The time when sugar was considered as the major, if not only, fuel to support cancer cell proliferation is over.” There seems to be “a fatter way to metastasize”. No marvel “…high-fat [diets may] …play a crucial role in increasing the risk of different cancer types, …[including] several advanced cancers.” Okay, if dietary fats could also be “greasing the wheels of the cancer machine,” may there be speciﬁc dietary regimens we may use to starve cancers of dietary fats? You don’t know till you place it to the check, which we’ll cowl subsequent.
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