Omega-3 dietary supplements are related to an elevated chance of growing atrial fibrillation in folks with high blood lipids. That’s the discovering of a examine printed right this moment in European Heart Journal – Cardiovascular Pharmacotherapy, a journal of the European Society of Cardiology (ESC).[1]

“Currently, fish oil dietary supplements are indicated for sufferers with elevated plasma triglycerides to cut back cardiovascular danger,”[2] mentioned examine writer Dr. Salvatore Carbone of Virginia Commonwealth University, US. “Due to the high prevalence of elevated triglycerides in the population, they can be commonly prescribed. Of note, low dose omega-3 fatty acids are available over the counter, without the need for a prescription.”

Some scientific trials have instructed that omega-3 fatty acids could also be related to an elevated danger for atrial fibrillation, the commonest coronary heart rhythm dysfunction. People with the dysfunction have a 5 instances better chance of getting a stroke.[3]

Omega-3 Fish Oil Supplements

These research examined totally different formulations of omega-3 fatty acids at totally different doses. The authors subsequently carried out a complete meta-analysis of randomized managed trials to reply the query of whether or not fish oils had been constantly associated to a raised danger for atrial fibrillation.

The evaluation included 5 randomized managed trials investigating the results of omega-3 fatty acid supplementation on cardiovascular outcomes. Participants had elevated triglycerides and had been both at high danger for heart problems or had established heart problems. A complete of 50,277 sufferers obtained fish oils or placebo and had been adopted up for between 2 and 7.4 years. The dose of fish oils assorted from 0.84 g to 4 g per day.

The researchers discovered that omega-3 fatty acid supplementation was related to a considerably elevated danger for atrial fibrillation in comparison with placebo with an incidence charge ratio of 1.37 (95% confidence interval 1.22-1.54; p<0.001).

Dr. Carbone mentioned: “Our examine means that fish oil dietary supplements are related to a considerably better danger of atrial fibrillation in sufferers at elevated cardiovascular danger. Although one scientific trial indicated helpful cardiovascular results of supplementation,[4] the chance for atrial fibrillation ought to be thought of when such brokers are prescribed or bought over-the-counter, particularly in people vulnerable to growing the guts rhythm dysfunction.”


  1. “Omega-3 fatty acids supplementation and risk of atrial fibrillation: an updated meta-analysis of randomized controlled trials” by Lombardi M, Carbone S, Del Buono MG, et al., 29 April 2021, European Heart Journal – Cardiovascular Pharmacotherapy.
    DOI: 10.1093/ehjcvp/pvab008
  2. Mach F, Baigent C, Catapano AL, et al. 2019 ESC/EAS Guidelines for the administration of dyslipidaemias: lipid modification to cut back cardiovascular danger. Eur Heart J. 2020;41:111-188.
  3. Hindricks G, Potpara T, Nikolaos Dagres N, et al. 2020 ESC Guidelines for the prognosis and administration of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2020.
    DOI: 10.1093/eurheartj/ehaa612
  4. Bhatt DL, Steg PG, Miller M, et al. Cardiovascular danger discount with icosapent ethyl for hypertriglyceridemia. N Engl J Med. 2019;380:11-22.

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